Individuals with schizophrenia and social anhedonia exhibit impaired neural processing for anticipation of social rewards

Summary: Individuals with schizophrenia and social anhedonia exhibit impaired neural processing for social reward processing, resulting in impaired social interaction and social dysfunction.

Source: chinese academy of sciences

Patients with schizophrenia and individuals with social anhedonia have been shown to exhibit impaired social reward processing that ultimately leads to impaired social interaction and social dysfunctions.

However, most previous studies of social reward anticipation in schizophrenia spectrum disorders have been limited to behavioral design. It is unclear whether the putative neural processing for social reward anticipation was altered in both people with schizophrenia and people with social anhedonia.

Recently, a research team led by Dr. Raymond Chan from the Institute of Psychology (IP) of the Chinese Academy of Sciences (CAS) conducted a study to specifically examine the neural mechanisms underlying reward anticipation. social in these populations.

The study was published in European Archives of Psychiatry and Clinical Neurosciences October 28.

The researchers recruited 23 people with schizophrenia and 17 healthy controls, as well as 37 people with social anhedonia and 50 healthy controls to perform the social prompting delay imaging task while they undertook brain MRIs.

They found that people with schizophrenia had hypo-activation of the left medial frontal gyrus and negative functional connectivities (FC) with left parietal regions.

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They found that people with schizophrenia had hypo-activation of the left medial frontal gyrus and negative functional connectivities (FC) with left parietal regions. Image is in public domain

However, individuals with social anhedonia exhibited hyper-activation of the left middle frontal gyrus when anticipating social reward.

Additionally, individuals with schizophrenia showed enhanced cerebellar-temporal FCs, while social anhedonic individuals showed enhanced FCs in the left frontal regions.

These results suggest that individuals with schizophrenia and social anhedonia exhibit impaired neural processing for social reward anticipation, and these neural activities show impaired association with actual social network characteristics.

The study advances our understanding of the neural underpinnings of social motivation in schizophrenia spectrum disorders.

About this mental health research news

Author: Li Yuan
Source: chinese academy of sciences
Contact: Li Yuan – Chinese Academy of Sciences
Image: Image is in public domain

Original research: Access closed.
“Altered neural mechanism of social reward anticipation in people with schizophrenia and social anhedonia” by Yi-jing Zhang et al. European Archives of Psychiatry and Clinical Neurosciences


Summary

Altered neural mechanism of social reward anticipation in people with schizophrenia and social anhedonia

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Impaired social reward anticipation could be found in patients with schizophrenia (SCZ) and people with high levels of social anhedonia (SA).

However, little research has investigated putative neural processing for impaired social reward anticipation in these populations on the SCZ spectrum.

This study aimed to examine the neural mechanisms underlying social reward anticipation in these populations.

Twenty-three SCZ patients and 17 healthy controls (HC), 37 SA individuals and 50 HC respectively completed the Social Incentive Delay (SID) imaging task while undertaking brain MRIs.

We used group contrast to examine alterations in BOLD activation and functional connectivity (FC, psychophysiological interaction analysis). We then characterized the beta-series social brain network (SBN) based on NeuroSynth meta-analysis results and examined their predictive effects on actual social network (SN) characteristics using the partial least squares regression analysis.

The results showed that SCZ patients had hypo-activation of the left medial frontal gyrus and negative FCs with left parietal regions, while individuals with AS had hyper-activation of the left middle frontal gyrus when anticipating a social reward. For beta-series SBNs, SCZ patients had strengthened cerebellar-temporal FCs, while SA individuals had strengthened FCs of the left frontal regions. However, these SBN FCs failed to predict the actual characteristics of the SN.

These preliminary results suggest that SCZ patients and SA individuals appear to exhibit impaired neural processing for social reward anticipation, and these neural activities showed an impaired association with actual SN characteristics.

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